The clinical efficacy of adefovir on chronic hepatitis B

Objective:To observe antiviral efficacy of adefovir on chronic hepatitis B.Methods:Thirty-four cases of patients with chronic hepatitis B were administered oral dose of 10 mg of adefovir once daily.HBVDNA,hepatic function and the serum HBV markers were detected every three months.Results:After 12 months′ treatment,HBVDNA converted to negative in 17 cases(50%).Among them,the HBVDNA negative conversion rate in patients whose HBVDNA was less than 107 cop/ml was 66.6%,and it was 23% in patients whose HBVDNA was≥107cop/ml.There was significant difference between these two kinds of patients(P0.05).The HBVDNA negative conversion rate in patients whose ALT was less than two folds of normal value was 20%,and it was 71.4% in patients whose ALT was more than two folds of normal value.There was also significant difference between these two kinds of patients(P0.05).There no correlation between HBVDNA negatives conversion rate and the mode of hepatitis B serum markers(P0.05).Conclusions:Adefovir is effective in HBVDNA negative conversion rate for the patients with low HBV load and high ALT levels.