Efficacy of Adefovir Dipivoxil for Patients with HBeAg Positive Chronic Hepatitis B and Its Influencing Factor

Objective: To observe the efficacy of domestic adefovir dipivoxil(ADV) in the treatment of patients with HBeAg positive chronic hepatitis B and analyse influencing related factors of the curative effect. Methods:118 HBeAg positive chronic hepatitis B patients were collected from 2005 June to 2011 September in our hospital .They were treated with domestic ADV for 48 weeks.The clinical data was collected. The efficacy was observed and the relevance of therapeutic and factors such as ALT level,HBVDNA level, body mass index ( BMI ) and age before treatment were analysed. Results: After 48 weeks,ALT recovery rate was 88%; HBVDNA negative rate was 43.22%; 22.03% patients′E antigen lost, 18.64% of them occurred E antibody serological conversion;and the resistant rate was 0%.The patients with HBVDNA negative conversion had the higher baseline ALT levels , the lower HBVDNA load, the smaller BMI, the higher percentage of obtaining Initial virologic response ( IVR ) at 24 weeks ,and they were younger. Conclusion: Domestic ADV can effectively inhibit HBVDNA replication,improve liver function,promote HBeAg serological conversion.The patients with the lower level of serum HBVDNA, the higher ALT levels,the lower BMI and the younger produce efficacy to ADV standard treatment more easily.