Study on Relationship between Expression of NF-κB and Metastasis in Non-Small Cell Lung Cancer

Objective:To investigate the relationship between the protein expression of nuclear factor kappa B(NF-κB) in tissue of non-small cell lung cancer (NSCLC) and the clinical pathological features.Methods:Expressions of NF-κBp65 protein in NSCLC tissue(n=95) and benign tumor tissue(n=27) were detected by immunohistochemical staining.The relationship between NF-κBp65 protein expression and clinical pathologic features was analysed.Results:Of the 58 samples which had lymph node metastasis,the expression level of NF-κBp65 protein was higher in 34 cases(58.6%).Of the 37 samples which had no lymph node metastasis,the expression level of NF-κBp65 protein was higher in only 8 cases (21.6%).The expression level of NF-κBp65 was significantly higher in metastasis group than that in non-metastasis group(χ2=12.537,P 0.01).There were significant differences in expression of NF-κBp65 between different histological types,differentiation degree and TNM stage of lung carcinoma.There was a positive correlation between the expression of NF-κBp65 protein and clinical stages (rs=0.502,P 0.05).A negative correlation was found between the expression of NF-κBp65 protein and histological differentiation grade (rs=-0.465,P 0.05).Conclusion:The detection of NF-κBp65 protein may be helpful to judge the malignancy and to evaluate the prognosis of NSCLC.