Effects of Zinc on Lead Content of Brain in Mice with Lead Sub-Chronic Exposure

[Objective] To study the effect of zinc on the lead content of brain in lead sub-chronic exposed mice,and to explore the antagonistic dose of zinc.[Methods ] Healthy Kunzea mice were divided randomly into 6 groups.The blank group,administrated with the distilled water;The lead poisoning group,administrated with 0.8 mg/10 g lead acetate water solution;The control group with high dose zinc were given high dose zinc acetate water solution;Zinc experiment groups were administrated with 0.8 mg/10 g lead acetate water solution and 3 doses zinc acetate water solution.All experiments were done once 3 days.The body weight and the death of mice were observed.3 months later,the mice were killed and brain weight and lead content were detected by the method of atomic absorption spectrometry.[Results ] Compared with lead poisoning group,lead contents in zinc experiment groups were decreased significantly and similar to the changes in zinc experiment groups.No difference was found between the blank group and zinc experiment groups.[Conclusion ] 3 doses of zinc could alleviate lead toxicity to the brain of mice,and could antagonize the absorption of lead.There is a significant antagonistic effect to lead exposed mice by low level dose of zinc.