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2013•Chinese Journal of Diagnostic PathologyRequires access

Expression of CD147 and matrix metalloproteinases-14 in gastrointestinal stromal tumors and their significance

Qiang Wu

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Abstract

Objective To investigate the relationship between the expression of matrix metalloproteinases-14 and clinical significance in gastrointestinal stromal tumors(GISTs).Methods Sixty-nine cases of GISTs were immunohistochemically studied for the expression of MMP-14 and CD147,and their relations with every pathologic parameters were analyzed statistically.Results Out of 69 cases,the positivity of MMP-14 and CD147 was 94.2% and 97.1 %,respectively.The expression levels of MMP-14 were significantly related to risk of GISTs,CD147 expression and size of tumors(P 0.05);The expression levels of CD147 were significantly related to size of tumors(P0.05).Conclusion MMP-14 is closely related with risk of GISTs,and therefore it might be a potential parameter for risk evaluation of GISTs.

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What this paper is about

Objective To investigate the relationship between the expression of matrix metalloproteinases-14 and clinical significance in gastrointestinal stromal tumors(GISTs).Methods Sixty-nine cases of GISTs were immunohistochemically studied for the expression of MMP-14 and CD147,and their relations with every pathologic parameters were analyzed statistically.Results Out of 69 cases,the positivity of MMP-14 and CD147 was 94.2% and 97.1 %,respectively.The expression levels of MMP-14 were significantly related to risk of GISTs,CD147 expression and size of tumors(P 0.05);The expression levels of CD147 were significantly related to size of tumors(P0.05).Conclusion MMP-14 is closely related with risk of GISTs,and therefore it might be a potential parameter for risk evaluation of GISTs.

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Available abstract

Objective To investigate the relationship between the expression of matrix metalloproteinases-14 and clinical significance in gastrointestinal stromal tumors(GISTs).Methods Sixty-nine cases of GISTs were immunohistochemically studied for the expression of MMP-14 and CD147,and their relations with every pathologic parameters were analyzed statistically.Results Out of 69 cases,the positivity of MMP-14 and CD147 was 94.2% and 97.1 %,respectively.The expression levels of MMP-14 were significantly related to risk of GISTs,CD147 expression and size of tumors(P 0.05);The expression levels of CD147 were significantly related to size of tumors(P0.05).Conclusion MMP-14 is closely related with risk of GISTs,and therefore it might be a potential parameter for risk evaluation of GISTs.

Key concepts: Medicine, Matrix metalloproteinase, Stromal cell, Immunohistochemistry, Pathology, Clinical significance, Oncology, Internal medicine

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Expression of CD147 and matrix metalloproteinases-14 in gastrointestinal stromal tumors and their significance — Research Paper | ScholarLens