Extracting Process of Aguiyangxue particles by the Continuous Counter-current Equipment

Objective To optimize the p-cyclodextrin inclusion process of Aguiyangxue particles under the application of multi-index comprehensive evaluation method combined with orthogonal experiment design.Methods Using the indexes of the rate of utilization of inclusion oil and the content of inclusion oil and the amount of the inclusion to investigate the oil-like substances/p-cyclodextrin(mI7g),inclusion time,inclusion temperature and ethanol/oil-like substances(%),and then to establish the optimical P-cyclodextrin inclusion process.Results The optimum p-cyclodextrin inclusion process:the oillike substances/β-cyclodextrin(mL/g) is 1:10,inclusion temperature is 40℃,and inclusion time is 1 h,ethanol/ oil-like substances(%) is 20%.Conclusion The β-cyclodextrin inclusion process of Aguiyangxue particles after the multi-index scores conbined with orthogonal experiment design provides a scientific basis for the clinical use.