Clinical Observation of Medium Dose of Ursodeoxycholic Acid for Primary Biliary Cirrhosis

OBJECTIVE:To observe clinical efficacy of moderate dose of ursodeoxycholic acid for primary biliary cirrhosis.METHODS:196 patients with primary biliary cirrhosis were divided into 2 groups.95 cases in the control group were given routine symptomatic therapy(liver protection,detoxification,diuretic,antibacterial).101 cases in treatment group were additionally given moderate dose of ursodeoxycholic acid on the basis of symptomatic therapy.A course of treatment lasted for 1 month.The therapeutic efficacy and liver function of 2 groups were investigated after 3 treatment courses.RESULTS:After 3 treatment courses,total effective rate of treatment group(79.2%) was significantly higher than that of control group(60.0%),there was statistical significance(P0.01);Results of liver function test showed that ALT and AST of treatment group decreased significantly(P0.01),was close to normal levels,GGB,ALT and TBA index hadn't returned to normal range,but was lower than before treatment(P0.01).CONCLUSION:The medium dose of ursodeoxycholic acid has obvious effect on primary biliary cirrhosis.