Studies on Cadmium Induced Immunotoxicity to Carassius ADuratus

Objective In order to study the effects of cadmium in water on immunity of fish.Method Carassius auratus was selected as the target fish and was raised in water with different concentrations of CdCl\-2.On the 10 th day,fish were killed and weighted,immune indexes,including total blood leucocyte numbers,serum lysozyme level,phagocytic rate and phagoindex of macrophage in pronephros,were determined.Results The results showed that,total blood leucocyte numbers of fish in low concentration of Cd(2 5μg/L) was significantly higher than that of control fish,while no difference existed among Cd 5 0 μg/L,Cd 10 0 μg/L and control.With the growth of cadmium concentration,there is an increasing tendency in serum lysozyme level,and lysozyme of fish in high dose of Cd(10 0 μg/L) was significant higher than that of control.Besides,there were no differences in phagocytic rate and phagoindex of macrophage in pronephors among various groups.Conclusion Our research indicated that Cd can induce immunotoxicity to Carassius auratus,research on effect of exnobiotics on fish immune function can be used as an effective biomarker in assessing water pollution.