ScholarLens Back to search
2011•Unpublished venueRequires access

Biological effects and liver biomarkers of PCB contamination on freshwater fish Carassius auratus

Yong Ji, Guanghua Lu

Open publisher page 0 citations

Abstract

Fresh fish Carassius auratus were chosen as experimental animals to study the potential of biological effects after fish were injected with different dose (0.001, 0.006, 0.03, 0.16, 0.78 mg/kg) of polychlorinated biphenyls (PCB). The hepatic biochemical responses to medium-term exposure of PCB were measured as reduced glutathione (GSH) and malondialdehyde (MDA) to assess sub-lethal effects. Clear dose-response relationships were found for liver GSH and MDA content of all concentrations. In most case, time dependence was apparent at higher concentration of 0.03 mg/kg. GSH and MDA in Carassius auratus were confirmed as useful biomarkers of exposure to PCB.

About this research paper

What this paper is about

Fresh fish Carassius auratus were chosen as experimental animals to study the potential of biological effects after fish were injected with different dose (0.001, 0.006, 0.03, 0.16, 0.78 mg/kg) of polychlorinated biphenyls (PCB). The hepatic biochemical responses to medium-term exposure of PCB were measured as reduced glutathione (GSH) and malondialdehyde (MDA) to assess sub-lethal effects. Clear dose-response relationships were found for liver GSH and MDA content of all concentrations. In most case, time dependence was apparent at higher concentration of 0.03 mg/kg. GSH and MDA in Carassius auratus were confirmed as useful biomarkers of exposure to PCB.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Fresh fish Carassius auratus were chosen as experimental animals to study the potential of biological effects after fish were injected with different dose (0.001, 0.006, 0.03, 0.16, 0.78 mg/kg) of polychlorinated biphenyls (PCB). The hepatic biochemical responses to medium-term exposure of PCB were measured as reduced glutathione (GSH) and malondialdehyde (MDA) to assess sub-lethal effects. Clear dose-response relationships were found for liver GSH and MDA content of all concentrations. In most case, time dependence was apparent at higher concentration of 0.03 mg/kg. GSH and MDA in Carassius auratus were confirmed as useful biomarkers of exposure to PCB.

Key concepts: Carassius auratus, Malondialdehyde, Glutathione, Fish <Actinopterygii>, Toxicity, Chemistry, Contamination, Ecotoxicology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Biological effects and liver biomarkers of PCB contamination on freshwater fish Carassius auratus — Research Paper | ScholarLens