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[Relationship between serum leptin and tumor necrosis factor and endothelin in patients with chronic renal failure].

Dao-you Zhang, Licai Yang, Jun Zhang, Xin-lu Zhang

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Abstract

OBJECTIVE: To assess the serum level of leptin and its relationship between tumor necrosis factor, and endothelin in patients with chronic renal failure. METHODS: Serum level of leptin,tumor necrosis factor and endothelin were measured in 40 patients with chronic renal failure and 20 healthy controls by radioimmunoassay. Correlation analysis was performed between serum level of leptin and tumor necrosis factor and endothelin. RESULTS: Serum leptin in patients with chronic renal failure was significantly higher than that in healthy control subjects((19.25+/-4.89)microg/L vs. (5.57+/-1.69)microg/L, P<0.01). There was significant positive correlation between serum leptin and tumor necrosis factor and endothelin (r(TNF)=0.829, r(ET)=0.605; both P<0.01). CONCLUSION: The abnormal increased serum levels of tumor necrosis factor and endothelin are associated with hyperleptinemia in patients with chronic renal failure.

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What this paper is about

OBJECTIVE: To assess the serum level of leptin and its relationship between tumor necrosis factor, and endothelin in patients with chronic renal failure. METHODS: Serum level of leptin,tumor necrosis factor and endothelin were measured in 40 patients with chronic renal failure and 20 healthy controls by radioimmunoassay. Correlation analysis was performed between serum level of leptin and tumor necrosis factor and endothelin. RESULTS: Serum leptin in patients with chronic renal failure was significantly higher than that in healthy control subjects((19.25+/-4.89)microg/L vs. (5.57+/-1.69)microg/L, P<0.01). There was significant positive correlation between serum leptin and tumor necrosis factor and endothelin (r(TNF)=0.829, r(ET)=0.605; both P<0.01). CONCLUSION: The abnormal increased serum levels of tumor necrosis factor and endothelin are associated with hyperleptinemia in patients with chronic renal failure.

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Available abstract

OBJECTIVE: To assess the serum level of leptin and its relationship between tumor necrosis factor, and endothelin in patients with chronic renal failure. METHODS: Serum level of leptin,tumor necrosis factor and endothelin were measured in 40 patients with chronic renal failure and 20 healthy controls by radioimmunoassay. Correlation analysis was performed between serum level of leptin and tumor necrosis factor and endothelin. RESULTS: Serum leptin in patients with chronic renal failure was significantly higher than that in healthy control subjects((19.25+/-4.89)microg/L vs. (5.57+/-1.69)microg/L, P<0.01). There was significant positive correlation between serum leptin and tumor necrosis factor and endothelin (r(TNF)=0.829, r(ET)=0.605; both P<0.01). CONCLUSION: The abnormal increased serum levels of tumor necrosis factor and endothelin are associated with hyperleptinemia in patients with chronic renal failure.

Key concepts: Medicine, Leptin, Internal medicine, Radioimmunoassay, Endocrinology, Tumor necrosis factor alpha, Endothelin receptor, Tumor necrosis factor α

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[Relationship between serum leptin and tumor necrosis factor and endothelin in patients with chronic renal failure]. — Research Paper | ScholarLens