2006•Unpublished venueRequires access

Effect of Extracts from Centella Asiatica on Intracellular Free Calcium Content of Rat Glomerular Mesangial Cells

Zhang Bianjiang

Abstract

Objective: To investigate the effect of extracts from Centella asiatica(ASA) on proliferaton and intracellular free calcium of rat glomerular mesangial cells(MC).Methods:Rat MC were incubated with angiotensin Ⅱ(AngⅡ),To observe the proliferation and intracellular free calcium concentration by the MTT method and flurescence measurement with Fura-2/AM after given the extracts from ASA.Results after stimulation of Angiotensin Ⅱ,the proliferation and intracellular free calcium concentration raised obviously,and ASA could dose-dependently inhibit the the proliferation and intracellular free calcium concentration.Conclusion ASA could inhibit MC proliferation by decreasing the intracellular free calcium concentration.

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Key concepts: Intracellular, Calcium in biology, Centella, Calcium, Chemistry, Stimulation, Renin–angiotensin system, Pharmacology