A Study on the Relationship Between the Abnormal Expression of TGF-β_1, TGF-βRIand Malignant Biological Behaviors in Ovarian Carcinoma

Objective To investigate the expression and significance of transforming growth factor-beta1(TGF-β 1),transforming growth factor-beta receptor typeⅠ(TGF-β RⅠ) in human ovarian carcinoma. Methods Inmmunohistochemical SP method was used to detect the expression of TGF-β 1 and TGF-β RI in 85 cases of benign and malignant ovarian tumors. Results The positive rate of TGF-β 1 in benign and malignant ovarian tumors was significantly higher than that in the normal ovarian tissues(P0.05); The frequency of TGF-β RⅠ middle and strong positive expression was remarkably lower in the malignant tumours than that in the benign ovarian tumors and normal ovarian tissues(P0.05). The abnormal expression of TGF-β 1 and TGF-β RⅠ was obviously associated with the clinical stages of ovarian carcinoma, but not with patients ages and ascites. TGF-β 1 was related to the histological type of malignant ovarian tumors, and negatively related with pathological staging and metastasis of ovarian carcinoma. Conclusion The abnormal expression of TGF-β 1 and TGF-β RⅠ was associated with the malignant biological behaviors in ovarian tumours, and may serve as a marker for predicting the prognosis of ovarian cancers. TGF-β 1 and TGF-β RⅠ may play an important role in the pathogenesis of ovarian carcinoma.