2002•PubMedRequires access

[Transforming growth factor-beta 1 expression in epithelial ovarian neoplasms and its clinical significance].

Xiaoyan Huang, Yilin Wu, Fengying Liu

Abstract

OBJECTIVE: To detect the expression of transforming growth factor-beta 1(TGF-beta 1) in epithelial neoplasms and its clinicopathologic features and prognosis. METHODS: TGF-beta 1 expression was detected in 77 cases of epithelial ovarian neoplasms by SABC immunohistochemistry (including 21 benign tissues, 7 borderline tissues, and 49 epithelial ovarian cancer tissues), and they were compared with 14 normal ovarian tissues. RESULTS: 1. The positive rate of TGF-beta 1 expression was 71.42% in the normal ovary, 76.19% in benign tissues, 4/7 in borderline tissues and 38.78% in epithelial ovarian cancer tissues. 2. TGF-beta 1 expression was associated with the grade, the FIGO stage, and the histologic type of the patients with epithelial ovarian cancer (P < 0.05). CONCLUSION: The expression of TGF-beta 1 may play an important role in the progression of epithelial ovarian cancer and may be related to the prognosis of epithelial ovarian cancers.

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Key concepts: Immunohistochemistry, Ovarian cancer, Ovary, Epithelium, Transforming growth factor beta, Epithelial ovarian cancer, Pathology, Stage (stratigraphy)