2000•Journal of North Sichuan Medical CollegeRequires access

Changes of serum superoxide dismutase and lipid peroxide levels in pneumonia children and their clinical significance

Zhu Hong-feng

Abstract

Objective:To approach the role of free redicals played in the pathogenesis of pneumonia.Methods:Serum superoxide dismutase(SOD)and lipid peroxide (LPO) levels were measured in children with pneumonia.Results:Compared to control,the LPO levels were significantly elevated and SOD levels and the SOD:LPO ratio significantly reduced in the acute phase of pneumonia (P0.01);the values almost returned to normal in the recovery phase.Conclusion:In the acute phase of pneumonia,oxidation of antibodies was hyperactive and antioxidation hypoactive;free radicals took part in and aggravated the pathogenesis of pneumonia;damage to the bodies by the radicals might be basically ceased in the recovery phase.

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Key concepts: Superoxide dismutase, Pathogenesis, Lipid peroxide, Pneumonia, Radical, Peroxide, Medicine, Immunology