The effects of long-term vasectomy on the serum testosterone, testis and epididymis tissues

Objective: To study the long-term effects of vasectomy on serum testosterone, testis and epididymis tissues and evaluate the value of vasectomy for male fertility control. Methods: 40 sexually mature rats were divided into two groups: control group and surgery group. The later were taken vasectomy. After 4, 6, 8, 10 months of operation, serum testosterone (ST) levels and its binding rate with ABP were detected, and testis and epididymis of model rats were observed. Meanwhile, we investigated the testicular tissue quantitatively with a TAS-plus automated image analyzer. Results: There were significant difference of testosterone levels between surgery and control groups after 6, 8, 10 months. Aseprtic inflammation was found in the testis and epididymis of surgery groups. Conclusions: Long-term vasectomy can reduce serum testosterone levels and cause some histological change in testis and epididymis.