Study on pathogens and antimicrobial resistance of urinary tract infection in children

Objective To investigate the new trend of pathogens and antimicrobial resistance of pathogens in children with urinary tract infection. Methods The clinical featrures, distribution of pathogens and the antimicrobial resistance of pathogens in 338 culture-positive hospitalized children with urinary tract infection from 2000 to 2006 were analyzed. Results Among 597 strains of bacterium, gram-negative bacilli accounted for 68.0% (with 40.2% of E Coli); gram-positive cocci accounted for 26.5% (with 17.8% of Enterococci); fungi accounted for 5.5%. Gram- negative bacilli had a high resistance rate towards Benzylpenicillin and many generations of cephalosporins, but it was very sensitive to imipenem and showed low resistance rate to aminoglycoside, quinolones and some second and third generation of cephalosporins. Enterobacteriae was 100% sensitive to vancomycin and showed low resistance rate to Furadantin. Conclusions E Coli is still the major pathogen in hospitalized children with complicated urinary tract infection. There is a tendency of increased proportion of Klebsiella and other enterobacteria. A substantial proportion of pathogens is resistant to antibiotics, some of which are mufti-resistant strains. Antimicrobial therapy should be initiated under the guidance of anti-microbial sensitivity test if possible.