2005•Clinical Education of General PracticeRequires access
Study on the blood coagulation, fibrinolysis and anticoagulation system indexes in patients with chronic pulmonary heart disease
Chen Bingy
Open publisher page 0 citations
Abstract
Objective To investigate the change of the blood coagulation, fibrinolysis and anti-coagulation system indexes in patients with chronic pulmonary heart disease during acute stage and recovery stage. Methods APTT, PT, plasma antithrombin activity(AT:C) and D-dimer concentration were measured in 62 patients with chronic pulmonary heart disease during acute stage and recovery stage , and 60 healthy controls, respectively. Results Comparing with healthy controls, all of the measured indexes in patients were significantly changed except PT in patients in recovery stage. In the patients during acute stage, APTT and PT were significantly shortened than those in recovery stage(P0.05), and FVIII:C, D-dimer were significantly increased(P0.05 and P0.01 respectively),whereas AT:C were significantly decreased (P0.05). Conclusion The results revealed that abnormality of the blood coagulation, fibrinolysis and anti-coagulation system were existed in the patients with chronic pulmonary heart disease. The patients showed high coagulation and fibribolysis activity, and low anti-coagulation activity. This situation was more serious in patients during acute stage than those in recovery stage.