2005•Chemical ReagentsRequires access
Study on the new synthetic method for 2-bromo-2-nitro-1,3-propanediol
Yang Hui-qiong
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Abstract
2-Bromo-2-nitro-1,3-propanediol was synthesized by bromination of nitromethane prior to condensation.This new method used no organic solvents and the intermediate bromonitro-methane could be easily purified.Moreover,the method was beneficial for industrialization.The optimum conditions of the reaction were for bromination,the molar ratio of sodium hydroxide to nitromethane was 1.11.0,sodium hydroxide concentration was 25%,temperatures of salt forming and bromination were -50 and 15 respectively;for condensation,the pH value of the solution was 56,temperature of condensation was 25,volume ratio of solvent to raw material was 2.01.0.The overall yield of production was 83.5% with 98% purity.