Combined detection of real-time tissue elastography and indicators of hepatic fibrosis in diagnosing hepatic fibrosis

Objective:To observe the clinical value of real-time tissue elastography(RTE) and indicators of hepatic fibrosis(HA,LN and IV-C) in diagnosing hepatic fibrosis in chronic hepatitis patients.Methods:Twenty-nine patients with chronic hepatitis,27 patients with cirrhosis and 25 who took physical examinations were enrolled.RTE was performed and indicators of hepatic fibrosis were measured by ELISA.Results:Thirty-six patients were RTE positive,20 were RTE negative.The sensitivity,specificity and the accuracy rate of RTE for diagnosing hepatic fibrosis was 96.30%(26/27),65.52%(19/29),80.36%(45/56) respectively,the indicators of hepatic fibrosis(HA,LN and IV-C) were apparently increased in both chronic hepatitis group and cirrhosis group(P0.01) compared with normal controls group.With the development of hepatic disease,the levels of HA and IV-C in cirrhosis group were apparently increased than that of in hepatitis group(P0.05).Conclusion:RTE is a new and promising sonography-based noninvasive method for the assessment of hepatic fibrosis in patients with chronic hepatitis B.The combined detection of RTE and indicators of hepatic fibrosis(HA,LN and IV-C) have great clinical significance in diagnosing hepatic fibrosis in chronic hepatitis patients,which can prognosticate the development of hepatic pathological change.