Clinical Efficacy of Budesonide and Ipratropium Bromide Combined with Aerosol Inhalation for Acute Exacerbation of Chronic Obstructive Pulmonary Disease

OBJECTIVE:To investigate the clinical efficacy of budesonide and ipratropium bromide combined with aerosol inhalation in the treatment of acute exacerbation of chronic obstructive pulmonary disease (COPD).METHODS:60 inpatients with acute exacerbation of COPD were randomly divided into treatment group(n=30) and control groups(n=30).Both groups received comprehensive treatment containing oxygen inhalation, antibiotics, facilitating expectoration, suppressing cough and relieving dyspnea, maintaining balance of water and electrolyte.Treatment group were additionally treated with budesonide suspension 2.0 mL and ipratropium bromide aerosols each 2.0 mL twice a day using compression aerosol inhalation machine for 1 week.The scores of dyspnea and lung function changes in 2 groups were observed before and after treatment.RESULTS:After 1 week, scores of dyspnea in 2 groups were significantly decreased after treatment(P0.05 or P0.01), and the decrease of dyspnea scores in treatment group was more significant than in control group(P0.05); lung function index of 2 groups was improved significantly after treatment (P0.05 or P0.01), and the improvement of lung function in treatment group was more significant than in control group(P0.05).CONCLUSION:Budesonide and ipratropium bromide combined with aerosol inhalation is effective in the treatment of acute exacerbation of COPD, and it can improve lung function and clinical symptoms significantly.