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Effect of breviscapine on biochemistry in hepatic ischemia-reperfusion injury

Xiaoqin Shi, Jingjing Zhang, Xiuping Liu, Baosheng Shi

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Abstract

Objective:To explor the role of breviscapine (Bre) on dynamic changes of lipid peroxidation in hepatic ischemia-reperfusion injury(HIRI).Methods:The HIRI model was used.Thirty-two rabbits were randomly divided into control group((n=8)),model group(n=8),Bre(5mg) group(n=8) and Bre(7mg) group(n=8).The superoxide dismutase(SOD) activity,malondialdehyde(MDA) content,glutathione peroxidase(GSHPX) and alanine aminotransferase(ALT) activity in serum were observed before ischemia and at ischemia 45 min,reperfusion 30min,reperfusion 60 min.Results:The SOD activity,GSH-PX activity MDA,content and ALT activity of Bre group,as compared with model group,showed significant differences((P0.05) or P0.01) at total time points of reperfusion.Conclusion:Bre has notable anti-lipid peroxidation effect on HIRI,which is due to its inhibiting the generation of oxygen free radicals and its strengthening scavenging of oxygen free radicals.

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Objective:To explor the role of breviscapine (Bre) on dynamic changes of lipid peroxidation in hepatic ischemia-reperfusion injury(HIRI).Methods:The HIRI model was used.Thirty-two rabbits were randomly divided into control group((n=8)),model group(n=8),Bre(5mg) group(n=8) and Bre(7mg) group(n=8).The superoxide dismutase(SOD) activity,malondialdehyde(MDA) content,glutathione peroxidase(GSHPX) and alanine aminotransferase(ALT) activity in serum were observed before ischemia and at ischemia 45 min,reperfusion 30min,reperfusion 60 min.Results:The SOD activity,GSH-PX activity MDA,content and ALT activity of Bre group,as compared with model group,showed significant differences((P0.05) or P0.01) at total time points of reperfusion.Conclusion:Bre has notable anti-lipid peroxidation effect on HIRI,which is due to its inhibiting the generation of oxygen free radicals and its strengthening scavenging of oxygen free radicals.

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Available abstract

Objective:To explor the role of breviscapine (Bre) on dynamic changes of lipid peroxidation in hepatic ischemia-reperfusion injury(HIRI).Methods:The HIRI model was used.Thirty-two rabbits were randomly divided into control group((n=8)),model group(n=8),Bre(5mg) group(n=8) and Bre(7mg) group(n=8).The superoxide dismutase(SOD) activity,malondialdehyde(MDA) content,glutathione peroxidase(GSHPX) and alanine aminotransferase(ALT) activity in serum were observed before ischemia and at ischemia 45 min,reperfusion 30min,reperfusion 60 min.Results:The SOD activity,GSH-PX activity MDA,content and ALT activity of Bre group,as compared with model group,showed significant differences((P0.05) or P0.01) at total time points of reperfusion.Conclusion:Bre has notable anti-lipid peroxidation effect on HIRI,which is due to its inhibiting the generation of oxygen free radicals and its strengthening scavenging of oxygen free radicals.

Key concepts: Malondialdehyde, Lipid peroxidation, Superoxide dismutase, Glutathione peroxidase, Chemistry, Alanine aminotransferase, Reperfusion injury, Ischemia

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