Impacts of Prealbumin Level on Short-term Prognosis of First Acute Cerebral Infarction Patients

Objective To explore the impacts of prealbumin( PA) on short-term prognosis in patients with first acute cerebral infarction. Methods A total of 345 first acute cerebral infarction patients who were treated in the Second Affiliated Hospital of Guangzhou Medical University from January 2010 to July 2013,were divided into with good outcome group( mRS score: 0-2,223 cases) and without good outcome group( mRS score: 3-6,122 cases) according to mRS score at the time of hospital discharge. Clinical features and serum PA level were compared between two groups. SPSS version 13. 0 statistical software was used for statistics. Results The age of onset,the prevalences of type 2 diabetes mellitus,ischemic heart disease and total anterior circulation infarcts( TACI) in without good outcome group were significantly higher than those in good outcome group,but the level of serum PA in without good outcome group was significantly lower than that in good outcome group 〔( 192 ± 58) mg / L vs.( 216 ± 57) mg / L; P 0. 05〕. The patients were divided into 4 groups according to quartile intercept point of serum PA level( 169,207 and 245 mg / L),mRS score of 4 groups at the time of hospital discharge was 2. 5( 2. 0),2. 0( 2. 0),1. 0( 2. 0) and 1. 0( 3. 0) respectively,the difference was statistically significant( P 0. 001). According to the results of Logistic regression analysis,advanced age,type 2 diabetes mellitus,ischemic heart disease,and TACI were independent risk factors for the poor outcome,and the OR values was 1. 028( P = 0. 007),2. 391( P = 0. 004),2. 308( P =0. 022) and 17. 625( P 0. 001) respectively. The high level of serum PA in the acute phase was the independent protective factor for the bad outcome,and the OR value was 0. 994( P = 0. 008). Conclusion The high level of serum PA in the acute phase is the independent protective factor for good short-term prognosis in first acute cerebral infarction patients.