2019•Int J Cerebrovasc DisRequires access
Correlation between serum uric acid level and short-term outcome of acute isolated pontine infarction
Xinsheng Han, Ning Liu, Jianke Xu, Gaocai Zhang, Hongyang Zhang, Miao Han, Yun Zhang
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Abstract
Objective
To investigate the correlation between serum uric acid level and short-term outcome of acute isolated pontine infarction.
Methods
From April 2016 to April 2018, consecutive patients with acute isolated pontine infarction admitted to the Department of Neurology, Kaifeng Central Hospital were enrolled. The baseline clinical data were collected. Fasting venous blood was collected on the day of admission or the morning of the next day for blood biochemical tests. The National Institutes of Health Stroke Scale (NIHSS) was used to assess the severity of neurological deficit. According to the modified Rankin Scale score at discharge or 14 d after onset, the patients were divided into good outcome group (≤2) and poor outcome group (>2). Multivariate logistic regression analysis was used to determine the independent risk factors for short-term poor outcome.
Results
A total of 137 patients were enrolled in the study, 108 (78.8%) had a good outcome, and 29 (21.2%) had a poor outcome. The baseline NIHSS score (median [interquartile range]: 2.5 [1.0-4.0] vs. 8.5 [5.5-10.0]; Z=6.092, P<0.001) and total cholesterol levels (4.290±0.101 mmol/L vs. 4.763±0.171 mmol/L; t=2.214, P=0.028] in the good outcome group were significantly lower than those in the poor outcome group, while serum uric acid level (329.769±8.122μmol/L vs. 257.103±14.290μmol/L; t=4.190, P<0.001) was significantly higher than that in the poor outcome group. Multivariate logistic regression analysis showed that high serum uric acid levels were independently associated with short-term good outcomes in patients with isolated pontine infarction (odds ratio [OR] 0.377, 95% confidence interval [CI] 0.203-0.702; P=0.002), while high NIHSS score (OR 1.762, 95% CI 1.375-2.258; P<0.001) and hypertension (OR 5. 353, 95% CI 1.333-21.502; P=0.018) were independently associated with short-term poor outcomes.
Conclusion
High baseline serum uric acid levels are associated with short-term good outcomes in patients with acute isolated pontine infarction.
Key words:
Cerebral infarction; Stroke; Brain ischemia; Pons; Uric acid; Magnetic resonance imaging; Treatment outcome; Prognosis; Biomarkers