2004•Yunnan Chemical TechnologyRequires access
Synthesis of Methyl 2-methyl-α-oxophenylacetate
Can Chen
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Abstract
Methyl 2-methyl-(-oxophenylacetate was synthesized by the hydrolysis of 2-methyl-α-oxobenzoyl cyanidewith concentrated sulfuric acid.Effect of concentrated sulfuric acid,reaction temperature,time and solvent on yields wasstudied.The ratio of 2-methyl-α-oxobenzoyl cyanide:sodium chloride:water:concentrated sulphuric acid was chosen as 10:1:10:10 and the mixture was kept in 45℃ for one hour to give the yield of 78%,with purity of 90.69%.