Effect of Removing Phlegm and Blood Stasis Decoction on Serum Levels of NO and PG I_2 in Patients with Hyperlipidemia

Objective:To observe the effect of Removing Phlegm and Blood Stasis Decoction on serum levels of nitric oxide(NO)and prostacyclin(PGI2)in patients with hyperlipidemia.Methods:90 patients of hyperlipidemia with syndrome of phlegm and blood stasis were randomly divided into 3 groups,30 cases of fluvastatin group were treated with oral fluvastatin.The Removing Phlegm and Blood Stasis Decoction high and low dose groups with 30 cases in each group,respectively,were given the high and low doses of Removing Phlegm and Blood Stasis Decoction orally,before and 4 weeks after treatment respectively,blood sampling for determination of NO and PGI2 contents and statistical analysis were made.Results:Before and after treatment,the NO and PGI2 levels of the 3 groups showed significant difference(P0.01,P0.05);NO and PGI2 levels between the high dose group of Removing Phlegm and Blood Stasis Decoction and fluvastatin group after treatment had no statistical significance(P0.05),while the above two groups compared with the low dose group of Removing Phlegm and Blood Stasis Decoction,there was significant difference(P0.05).Conclusion:Removing Phlegm and Blood Stasis Decoction can elevate serum levels of NO and PGI2 in patients with hyperlipidemia,and is positively related to the dosage.It can prevent and treat atherosclerotic and delay the onset of cardiovascular and cerebrovascular diseases.