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2011•Journal of Modern UrologyRequires access

A clinical study on intermittent finasteride therapy for benign prostatic hyperplasia

Shao-bin Zheng

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Abstract

Objective To evaluate the outcome of intermittent finasteride for the treatment of benign prostatic hyperplasia(BPH).Methods 60 patients with BPH were equally divided into 3 groups at random,including 1/d,1/2ds and 1/3ds finasteride intaking groups.All the patients were followed up for 6 months.IPSS score,QOL score,serum level of PSA,Qmax,date from ultrasound examination and evaluation of IIEF-5 were observed.Results The study on 1/3ds finasteride intaking group was cancelled ahead of schedule for high incidence of exacerbation.No significant difference was found between the 1/d and 1/2ds groups.Conclusions 1/2ds intermittent finasteride intake may be as effective as daily administration for the treatment of BPH.

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What this paper is about

Objective To evaluate the outcome of intermittent finasteride for the treatment of benign prostatic hyperplasia(BPH).Methods 60 patients with BPH were equally divided into 3 groups at random,including 1/d,1/2ds and 1/3ds finasteride intaking groups.All the patients were followed up for 6 months.IPSS score,QOL score,serum level of PSA,Qmax,date from ultrasound examination and evaluation of IIEF-5 were observed.Results The study on 1/3ds finasteride intaking group was cancelled ahead of schedule for high incidence of exacerbation.No significant difference was found between the 1/d and 1/2ds groups.Conclusions 1/2ds intermittent finasteride intake may be as effective as daily administration for the treatment of BPH.

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Available abstract

Objective To evaluate the outcome of intermittent finasteride for the treatment of benign prostatic hyperplasia(BPH).Methods 60 patients with BPH were equally divided into 3 groups at random,including 1/d,1/2ds and 1/3ds finasteride intaking groups.All the patients were followed up for 6 months.IPSS score,QOL score,serum level of PSA,Qmax,date from ultrasound examination and evaluation of IIEF-5 were observed.Results The study on 1/3ds finasteride intaking group was cancelled ahead of schedule for high incidence of exacerbation.No significant difference was found between the 1/d and 1/2ds groups.Conclusions 1/2ds intermittent finasteride intake may be as effective as daily administration for the treatment of BPH.

Key concepts: Finasteride, Medicine, Hyperplasia, Urology, Incidence (geometry), Exacerbation, Prostate, Internal medicine

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