ScholarLens Back to search
2011•Chinese Journal of Laboratory DiagnosisRequires access

Effection of Nimodipine on vascular endothelial cell apoptosis induced by various concentrations of ox-LDL

Fang Yu

Open publisher page 0 citations

Abstract

Objective To study the effect to Nimodipine on vascular endothelial cell apoptosis induced by various concentrations of ox-LDL.Methods Cultured vascular endothelial(ECV304) were treated with various concentrations o of ox-LDL and Nimodipine for 6～24 hours.A transmission electron microscope was employed to observe the cell apoptosis.The apoptosis rate of ECV304 cell was anaylzed with flow cytometer.The concentration of Ca2+ was detected by a laser scanning confocal microscope(LCSM).Results ox-LDL was able to induce apoptosis in human ECV304 cells.Nimodipine could inhibit apoptosis of ECV304 cells.Conclusion Nimodipine could protect ECV304 cells from various concentrations of ox-LDL induced apoptosis.

About this research paper

What this paper is about

Objective To study the effect to Nimodipine on vascular endothelial cell apoptosis induced by various concentrations of ox-LDL.Methods Cultured vascular endothelial(ECV304) were treated with various concentrations o of ox-LDL and Nimodipine for 6～24 hours.A transmission electron microscope was employed to observe the cell apoptosis.The apoptosis rate of ECV304 cell was anaylzed with flow cytometer.The concentration of Ca2+ was detected by a laser scanning confocal microscope(LCSM).Results ox-LDL was able to induce apoptosis in human ECV304 cells.Nimodipine could inhibit apoptosis of ECV304 cells.Conclusion Nimodipine could protect ECV304 cells from various concentrations of ox-LDL induced apoptosis.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To study the effect to Nimodipine on vascular endothelial cell apoptosis induced by various concentrations of ox-LDL.Methods Cultured vascular endothelial(ECV304) were treated with various concentrations o of ox-LDL and Nimodipine for 6～24 hours.A transmission electron microscope was employed to observe the cell apoptosis.The apoptosis rate of ECV304 cell was anaylzed with flow cytometer.The concentration of Ca2+ was detected by a laser scanning confocal microscope(LCSM).Results ox-LDL was able to induce apoptosis in human ECV304 cells.Nimodipine could inhibit apoptosis of ECV304 cells.Conclusion Nimodipine could protect ECV304 cells from various concentrations of ox-LDL induced apoptosis.

Key concepts: Nimodipine, Apoptosis, Flow cytometry, Confocal, Cell, Endothelial stem cell, Chemistry, Cell biology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Effection of Nimodipine on vascular endothelial cell apoptosis induced by various concentrations of ox-LDL — Research Paper | ScholarLens