2013•Zhonghua zhongyiyao xuekanRequires access

Optimization of Extraction Method of Vinblastine Catharanthine and Vindoline from Fresh Catharanthus Roseus

Zhichao Dong

Abstract

Objective:To study the optimal procedure of extracting vinblastine,catharanthine and vindoline from fresh Catharanthus roseus(L.) G.Don(bright-eyes,rose periwinkle,Madagascar periwinkle).Methods:The extraction method was optimized with orthogonal experimental design and RP-HPLC method was used to determine the contents of vinblastine,catharanthine and vindoline from fresh C.roseus.Results:The orthogonal experimental result showed that the optimal condition was as follows: ratio of fresh C.roseus(g) and solvent(mL) was 1∶ 10,extracting time of 14 hours and pH value was 0.5.Conclusion:It can increase the extraction yield of effective components from fresh C.roseus.The optimal method is simple and useful for the large-scale production.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Vindoline, Catharanthus roseus, Vinblastine, Extraction (chemistry), Chromatography, Apocynaceae, Botany, Yield (engineering)