Changes and significance of serum stromal cell-derived factor-1,matrix metalloproteinase-9 in type 2 diabetes mellitus patients

【Objective】 To study the value of serum Stromal cell-derived factor-1(SDF-1),Matrix metalloproteinase-9(MMP-9) levels in type 2 diabetes mellitus(T2DM) patients.【Methods】 120 cases patients with T2DM were divided into simple diabetic group(SDM,32 cases),vascular disease group(VD,88 cases).A total of 30 healthy people were enrolled as control group(NC).The level of serum SDF-1,the number of Endothelial progenitor cells(EPCs) and the positive rate of CXCR4 which is receptor of SDF-1 dwelling on the membrane of EPCs from peripheral blood were determined.【Results】 The level of serum SDF-1 and the number of EPCs were decreased by degrees from NC to SDM,VD groups(P 0.05 or 0.01);The level of serum MMP-9 was increased by degrees from NC to SDM,VD groups(P 0.01);Compared with the other groups,the positive rate of CXCR4 in SDM group was increased(P 0.05 or 0.01),which is lower in VD group than in SDM group(P 0.05).The SDF-1 level was correlated negatively with MMP-9(r =-0.223,P 0.05),positively with EPCs(r =0.224,P 0.05);There was a negative correlation between the level of MMP-9 and the number of EPCs(r =-0.215,P 0.05).【Conclusion】 The changes of SDF-1/CXCR4 from peripheral blood may be related to the number and effect of EPCs,MMP-9 may play a role in vascular disease by reducing the level of SDF-1.