Influence of OA Knee Pad on Cartilage Cell Proliferation and Apoptosis of Rabbit with Knee Osteoarthritis

Objective:To investigate the influence of the OA knee pad on cartilage cell proliferation and apoptosis of rabbits with knee osteoarthritis.Methods:54 rabbits of 6-months-old copied knee osteoarthritis by modified Hulth Law were randomly divided into 6 groups.Normal group received the conventional breeding,model group received conventional breeding after modeled,and control group received the microwave therapy.Experimental group 1 received the electricity(density wave) in the treatment,experimental group 2 received the hot(hot soft membrane) in the treatment and experimental group 3 received electrothermal(OA knee pad) in the treatment,30 minutes each once,once a day.All of them were killed after the treatment for 16 weeks.The cartilage cell proliferation and apoptosis was detected by immunohistochemical method.Results:After 16 weeks,the cartilage cell apoptosis rate was significantly higher in test group than normal group(P0.01,P0.05),control group,experimental group 1,2 and 3 was significantly lower than model group(P0.01,P0.05),experimental group 3 was significantly lower than control group,experimental group 1 and 2(P0.05).Articular cartilage cell proliferation rate,the test group was significantly lower than normal group(P0.01,P0.05),control group,experimental group 1,2 and 3 was significantly higher than model group(P0.01,P0.05),experimental group 3 was significantly higher than control group,experimental group 1 and 2(P0.05).Conclusion:OA knee articular cartilage can be effective in promoting cell proliferation,inhibit chondrocyte apoptosis.