Treatment of 35 cases of early diabetic nephropathy of qi-yin deficiency by combined "Tang Shen Ning" with western conventional therapy

Objective To observe the clinical effect of Tang Shen Ning combined with western conventional therapy for early diabetic nephropathy of qi-yin-deficiency.Methods Seventy subjects were randomized into two groups: control group in which 35 cases were treated by western conventional therapy,and treatment group in which 35 cases were treated with Tang Shen Ning and western conventional therapy,with a course of 3 months.Clinical efficacy,symptom scores,fasting blood glucose,24h urine albumin,blood lipids,endothelin and hypersensitive C-reactive protein were observed before and after treatment.Results The total effective rate was 85.71% in treatment group and 62.86% in control group,with a difference between them(P0.05).After treatment,the major symptom score decreased obviously in the treatment group(P0.05),and decreased little in the control group(P0.05),with a difference between the two groups(P0.05).Fasting blood glucose did not reduce in both groups afer treatment(P0.05).After treatment,24h urinary albumin excretion,triglyceride,low density lipoprotein,hypersensitive C-reactive protein and endothelin in the treatment group decreased significantly(P0.05);24h urinary albumin excretion and ET in the control group decreased(P0.05);there were significant differences in 24h urinary albumin excretion,triglyceride,low density lipoprotein and hypersensitive C-reactive protein between the two groups(P0.05).Conclusion Tang Shen Ning can regulate blood lipid,improve endothelial function,relieve inflammation and reduce urinary albumin to prevent diabetic nephropathy.