The clinical value of MCV,MCH United Hb electrophoresis indexes on screening thalassemia

OBJECTIVE To study the value of the tests of mcv,mch and hemoglobin(Hb)electrophoresis analyses in diagnosis of thalassemia,and practice prenatal diagnosis on the couples at high risk of having fetus with thalassemia,especially for those who preliminary selection positive or/and the couples carry identity gene.Finally,we aimed to prevent having fetus with thalassemia major.METHODS MCV,MCH and United Hb electrophoresis were used to conduct the prenatal screening.RESULTS The number of thalassemia screened was 3720,and the positive rate was 20.56%.There were α-thalassemia 445 cases of all the cases,and the positive rate was 11.96%.There were β-thalassemia 320 cases,and the positive rate was 8.60%.The Genetic diagnosis of thalassemia were 545 cases.The coverage rate of repeated screening rate was 14.65%.Of them,there were α-thalassemia 308 cases,and account for 8.28%.There were β-thalassemia 185 cases,and account for 4.79%.There were complex thalassemia 52 cases,and accounted for 1.40%.CONCLUSION MCV,MCH and hemoglobin electrophoresis could use as positive indexes on screening thalassemia,combined with genetic diagnosis,and shows great significance in screening and diagnosis Thalassemia.