Mechanism of improving insulin resistance in type 2 diabetes with the method of supplementing Qi and nourishing Yin,removing phlegm to resolve blood stasis

Objective To discuss the possible mechanism of improving insulin resistance in type 2 diabetes mellitus(T2DM) with the method of supplementing Qi and nourishing Yin,removing phlegm to resolve blood stasis. Methods Eighty patients with T2DM were randomly divided into treatment group and control group,40 cases were given basic treatment,the treatment group had taken Chinese medicine drugs and the control group had taken Avandia,8 weeks was a course of treatment. Before and after treatment,the changes in FPG,FINS,HOMA-IR,blood lipids,and TNF-α,leptin,adiponectin were observed. Results The treatment group significantly improved TNF-α,leptin,ADP level,and better than control group; the two groups had equal effect in improving insulin resistance; the treatment group significantly improved blood lipids level,and these indexes were superior to those in control group. Conclusion Improving inflammation and leptin resistance in patients with type 2 diabetes may be the possible mechanism of improving insulin resistance for the method of supplementing Qi and nourishing Yin,removing phlegm to resolve blood stasis.