Therapeutic effect of high-dose three-dimensional conformal radiotherapy for patients with advanced non-small-cell lung cancer

Objective To evaluate the efficiency of high-dose three-dimensional conformal radiotherapy and the risk of radiation injury in patients with non-small cell lung cancer(NSCLC). Methods 80 patients with histological confirmed carcinoma of the NSCLC were randomized into two groups to patients of high-dose fraction three-dimensional conformal radiotherapy(3D-CRT) were treated with high-dose three-dimensional conformal radiotherapy at the total dose of 60Gy in 15 fractions implemented in a course of 3 weeks,4Gy for each fraction and the other 40 patients underwent conventional fraction three-dimensional conformal radiotherapy at the total dose of 60 to 68Gy in 30 to 34 fractions completed in 6 to 7 weeks. Results The 1,2,3 year of local control in high-dose fraction three-dimensional conformal radiotherapy group were better than the conventional fraction three-dimensional conformal radiotherapy (65.0% vs 40.0% ,50.0% vs 27. 5% ,27. 5% vs 10. 0% , P 0. 05),and the 1,2,3 year of survival rate in high-dose fraction three-dimensional conformal radiotherapy group were also better than the conventional fraction three-dimensional conformal radiotherapy(80.0% vs 60. 0% , 70. 0% vs 47. 5% ,60. 0% vs 37.5% ,P 0.05).The side effections of high-dose fraction three-dimensional conformal radiotherapy group were not significant. Conclusion High-dose fraction three-dimensional conformal radiotherapy has better therapeutic effect in advanced NSCLC and no more radiation-induced injure happens.