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Significance of monocyte chemotactic protein-1 in specimens of proliferative vitreoretinopathy

Han Quan

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Abstract

AIM To investigate the relationship between the presence of MCP 1 and macrophages and T lymphocytes in specimens obtained from retinal detachment and PVR eyes. METHODS Specimens were obtained during retinal surgery, including cellular components of subretinal fluids in rhegmatogenous retinal detachment (RD), fluids collections during vitrectomy for PVR grade B, and epiretinal membranes from PVR grade C or D. Immunohistochemical detection was performed to examine the distribution of MCP 1, and the presence of CD 68 or CD 3 positive cells in these specimens. RESULTS The expression of MCP 1 was negative or very weak in cells of subretinal fluid from RD. As a function of the increase of PVR grade, MCP 1 expression became stronger while the rate of CD 68 (+)/CD 3 (+) decreased. CONCLUSION MCP 1 may modulate the wound healing after retinal detachment and the formation of epiretinal membranes in PVR.

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What this paper is about

AIM To investigate the relationship between the presence of MCP 1 and macrophages and T lymphocytes in specimens obtained from retinal detachment and PVR eyes. METHODS Specimens were obtained during retinal surgery, including cellular components of subretinal fluids in rhegmatogenous retinal detachment (RD), fluids collections during vitrectomy for PVR grade B, and epiretinal membranes from PVR grade C or D. Immunohistochemical detection was performed to examine the distribution of MCP 1, and the presence of CD 68 or CD 3 positive cells in these specimens. RESULTS The expression of MCP 1 was negative or very weak in cells of subretinal fluid from RD. As a function of the increase of PVR grade, MCP 1 expression became stronger while the rate of CD 68 (+)/CD 3 (+) decreased. CONCLUSION MCP 1 may modulate the wound healing after retinal detachment and the formation of epiretinal membranes in PVR.

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Available abstract

AIM To investigate the relationship between the presence of MCP 1 and macrophages and T lymphocytes in specimens obtained from retinal detachment and PVR eyes. METHODS Specimens were obtained during retinal surgery, including cellular components of subretinal fluids in rhegmatogenous retinal detachment (RD), fluids collections during vitrectomy for PVR grade B, and epiretinal membranes from PVR grade C or D. Immunohistochemical detection was performed to examine the distribution of MCP 1, and the presence of CD 68 or CD 3 positive cells in these specimens. RESULTS The expression of MCP 1 was negative or very weak in cells of subretinal fluid from RD. As a function of the increase of PVR grade, MCP 1 expression became stronger while the rate of CD 68 (+)/CD 3 (+) decreased. CONCLUSION MCP 1 may modulate the wound healing after retinal detachment and the formation of epiretinal membranes in PVR.

Key concepts: Proliferative vitreoretinopathy, Vitrectomy, Epiretinal membrane, Retinal detachment, Retinal, Monocyte, Ophthalmology, Immunohistochemistry

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Significance of monocyte chemotactic protein-1 in specimens of proliferative vitreoretinopathy — Research Paper | ScholarLens