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Expression and Clinical Significance of CD105、CD34 in Human Glioma

Yong-peng Cui

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Abstract

Objective:To compare the expression of CD105,CD34 and investigate the relationship between the microvessel density (MVD) marked with anti-CD105,anti-CD34 antibody and the clinicopathologie grade in human gIioma.Methods:Im- munohistochemical method was used to analyze the expression of CD105,CD34 in 46 case of human glioma.Results..the expres- sion of CD105,CD34 in human glioma is higher than that of the normal brain issue.The expression of CD105 is more specifici- ty than that of CD34 in human glioma.MVD marked with CD105,CD34 antibody were positively correlated with the malignant grades(r_s=0.824,P＜0.01;r_s=0.675,P＜0.01)in glioma.Conclusion:The expression of CD105 is more specificity than that of CD34 in human glioma.MVD marked with CD105 antibody may be a valuable marker for judging the malignant grades and predicting the risk of development in glioma,and this marker is superior to MVD marked with CD34.

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Objective:To compare the expression of CD105,CD34 and investigate the relationship between the microvessel density (MVD) marked with anti-CD105,anti-CD34 antibody and the clinicopathologie grade in human gIioma.Methods:Im- munohistochemical method was used to analyze the expression of CD105,CD34 in 46 case of human glioma.Results..the expres- sion of CD105,CD34 in human glioma is higher than that of the normal brain issue.The expression of CD105 is more specifici- ty than that of CD34 in human glioma.MVD marked with CD105,CD34 antibody were positively correlated with the malignant grades(r_s=0.824,P＜0.01;r_s=0.675,P＜0.01)in glioma.Conclusion:The expression of CD105 is more specificity than that of CD34 in human glioma.MVD marked with CD105 antibody may be a valuable marker for judging the malignant grades and predicting the risk of development in glioma,and this marker is superior to MVD marked with CD34.

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Available abstract

Objective:To compare the expression of CD105,CD34 and investigate the relationship between the microvessel density (MVD) marked with anti-CD105,anti-CD34 antibody and the clinicopathologie grade in human gIioma.Methods:Im- munohistochemical method was used to analyze the expression of CD105,CD34 in 46 case of human glioma.Results..the expres- sion of CD105,CD34 in human glioma is higher than that of the normal brain issue.The expression of CD105 is more specifici- ty than that of CD34 in human glioma.MVD marked with CD105,CD34 antibody were positively correlated with the malignant grades(r_s=0.824,P＜0.01;r_s=0.675,P＜0.01)in glioma.Conclusion:The expression of CD105 is more specificity than that of CD34 in human glioma.MVD marked with CD105 antibody may be a valuable marker for judging the malignant grades and predicting the risk of development in glioma,and this marker is superior to MVD marked with CD34.

Key concepts: Endoglin, CD34, Glioma, Medicine, Pathology, Cancer research, Stem cell, Biology

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