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2012•Journal of Hubei University of Chinese MedicineRequires access

Effect of Curcumin on Growth of Human Colon Carcinoma Cell Line HCT-116

Gang Zhao

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Abstract

Objective To observe the effect of curcumin on the growth and proliferation of human colon cancer cell line HCT-116 in vitro.Methods The HCT-116 cells were treated with 10-80μmol/L curcumin for 48 hours respectively.The morphological changes of HCT-116 cells were observed with inverted microscope,The effects of curcumin on the growth of HCT-116 cells were detected by MTT assay.Results MTT method revealed that curcumin could inhibit the growth and proliferation of HCT-116 cells in a dose-dependent manner.Except low dose(10μmol/L)group,other dose curcumin treated group(20 μmol/L、40μmol/L、80μmol/L)had significant difference compared with negative control group(P0.05).And the growth inhibit rates of these curcumin groups had significant difference compared with the control group(P0.05).Conclusion Curcumin could inhibit the growth and proliferation of HCT-116 cells in a dose-dependent manner in vitro.

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What this paper is about

Objective To observe the effect of curcumin on the growth and proliferation of human colon cancer cell line HCT-116 in vitro.Methods The HCT-116 cells were treated with 10-80μmol/L curcumin for 48 hours respectively.The morphological changes of HCT-116 cells were observed with inverted microscope,The effects of curcumin on the growth of HCT-116 cells were detected by MTT assay.Results MTT method revealed that curcumin could inhibit the growth and proliferation of HCT-116 cells in a dose-dependent manner.Except low dose(10μmol/L)group,other dose curcumin treated group(20 μmol/L、40μmol/L、80μmol/L)had significant difference compared with negative control group(P0.05).And the growth inhibit rates of these curcumin groups had significant difference compared with the control group(P0.05).Conclusion Curcumin could inhibit the growth and proliferation of HCT-116 cells in a dose-dependent manner in vitro.

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Available abstract

Objective To observe the effect of curcumin on the growth and proliferation of human colon cancer cell line HCT-116 in vitro.Methods The HCT-116 cells were treated with 10-80μmol/L curcumin for 48 hours respectively.The morphological changes of HCT-116 cells were observed with inverted microscope,The effects of curcumin on the growth of HCT-116 cells were detected by MTT assay.Results MTT method revealed that curcumin could inhibit the growth and proliferation of HCT-116 cells in a dose-dependent manner.Except low dose(10μmol/L)group,other dose curcumin treated group(20 μmol/L、40μmol/L、80μmol/L)had significant difference compared with negative control group(P0.05).And the growth inhibit rates of these curcumin groups had significant difference compared with the control group(P0.05).Conclusion Curcumin could inhibit the growth and proliferation of HCT-116 cells in a dose-dependent manner in vitro.

Key concepts: Curcumin, In vitro, MTT assay, Growth inhibition, Cell growth, Chemistry, Significant difference, Cell culture

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