1999•Unpublished venueRequires access
DNA gel electrophoretic and microautoradiographic studies on apoptosis in bone tumor cells after exposure to 153 Sm\|EDTMP\
Han Xiaofen
Open publisher page 0 citations
Abstract
Objective To study the characteristics of injury in apoptotic bone tumor cells and behavior of radionuclide \{\}\+\{153\}Sm in tumor cells. Methods DNA gel electrophoresis and microautoradiographic tracing of apoptotic bone tumor cells at different intervals after \{\}\+\{153\}Sm\|EDTMP internal irradiation. Results Bone tumor cells internally irradiated with 153 Sm\|EDTMP displayed characteristics of DNA ladder formation in apoptotic cells. 153 Sm could permeate through tumor cell membrane and be phagocytized by the tumor cells,showing membrane\|seeking and membrane bounded apoptotic bodies condensation. Conclusion Progression of apoptosis in bone tumor cells induced by 153 Sm\|EDTMP is dependent on the time elapse of 153 Sm internal irradiation.\;