A study of the dosage of rhGH on the treatment of the geratic thoracic and abdominal postoperative patients with acute respiratory failure

Objective To explore the ideal dose of rhGH on the treatment of the geratic thoracic and abdominal postoperative patients with acute respiratory failure.Methods 45 geratic surgery postoperative patients with acute respiratory failure were randomly divided into three groups(A,B,C group).Patients in rhGH group A were given rhGH 4IU twice a day for ten days continuously by intramuscular injection.Patients in rhGH group B were given rhGH 4IU once a day for ten days continuously by intramuscular injection.Patients in control group C were admitted to ICU at the same time but not given rhGH.Other treatments were same in three groups.Time of mechanical ventilation,incidence of ventilator-associatcd pneumonia(VAP),average time of in ICU,fatality rate in ICU,achievement ratio of once extubation,blood glucose in the tenth day and dosage of insulin everyday were observed and compared in the three days.Results Compare with the control group,time of mechanical ventilation and average time of in ICU in the treatment group A and B showed a statistically shorter(P0.05);incidence of VAP,fatality rate in ICU and achievement ratio of once extubation in the treatment group A and B showed a statistically more improvement(P0.05);dosage of insulin everyday in the treatment group A and B was more than that in control group(P0.05),but in the controllable range.Conclusion The rhGH dose in the range of daily 4IU or 8IU for 10 days is safe for the geratic thoracic and abdominal postoperative patients with acute respiratory failure in ICU.But the monitor of blood glucose and intensive insulin therapy(IIT) should be enhanced in order to prevent glycometabolic disturbance.