Effect of Qifuyin on Ability of Learning and Memory and Expression of Somatostatin in Hippocampus on Model Rats of Alzheimer’s Disease Induced by β-amyloid_(1-42)

Objective To observe the effects of Qifuyin on learning and memory ability and expression of somatostatin in hippocampus on Alzheimer’s disease (AD) rats. Methods SD rats were randomly divided into blank control group, sham operation control group, model group, donepezil group and Qifuyin group. The AD model was established by microinjection of Aβ1-42 into the bilateral hippocampus. The learning and memory ability of rats were evaluated with a series of tasks to find a hidden platform in Morris Water Maze. The expression levels of somatostatin in hippocampus were measured by immunohistochemical SP techniques. Results In the place navigation test, the mean escape latencies of the model group was obviously increased compared with sham operation control group (P0.05). The mean escape latency of Qifuyin [2.15, 4.3, 8.6 mg/(kg·d)] group was obviously increased compared with the model group (P 0.05). The expression of somatostatin in hippocampus of Qifuyin [2.15, 4.30, 8.60 mg/(kg·d)] group was obviously increased compared with sham operation control group and model group. Conclusions Qifuyin has an effect of improving learning and memory ability of AD rats, which is possibly due to the promotion of the expression of somatostatin in hippocampus.