The Clinical Value of Neuron-specific Enolase Concentrations in Serum of Newborn with Hypoxic Ischemic Encephalopathy

Objective:To evaluate the neuron-specific enolase concentrations in serum of newborn with hypoxic ischemic encephalopathy.Method:Sixty-three cases of newborn with HIE(including 21 cases mild HIE,22 cases moderate HIE,20 cases severe HIE) and the healthy control group(22 cases) were studied.The serum neuron specific enolase(NSE) were tested by enzyme-linked immunosorbent assay(ELISA).Result:The mean serum NSE concentrations before and after treatment in mild HIE group was 13.49±4.37ug/L and 11.47±4.15ug /L respectively(P 0.05,t = 2.118).in moderate HIE group was 14.95±4.58ug/L and 12.21±5.28ug/L respectively(P 0.05,t = 2.120).in severe HIE group was 15.34±4.58ug/L and 12.97±5.81ug/L respectively(P 0.05,t = 2.314),and in the normal control group was 9.15±4.82 ug / L.The mean serum NSE concentrations before treatment in HIE infants were significantly increased compared with healthy newborn,the difference was significant(F = 4.61,P 0.05),and it was positively correlated with the severity degree of HIE.Conclusion:The serum NSE is a good marker for the evaluation of HIE degree and the therapeutic effects.