Comparison of experimental study of MR enhanced pulmonary perfusion imaging and SPECT pulmonary perfusion in pulmonary embolism

Objective:Comparison of the diagnostic value of MR pulmonary perfusion and SPECT pulmonary perfusion in pulmonary embolism.Methods:24 rabbits were modeled pulmonary embolism. Gd-DTPA were injected from rabbit's vein, MR perfusion imaging of 3D-FLASH sequence was performed after 6h.Time-signal intensity curve was scaled in ROI of coronal original images. Then SPECT pulmonary perfusion imaging was made.The rabbits were sacrificed and observed for the pathological changes. To test for statistical significance, t test and χ~2 test were performed.Results:20 rabbits were modeled successfully. The enhanced rate of normal pulmonary tissue and embolismic pulmonary tissues were 317.5%, 45.1% respectively. The perfusion peak value of normal pulmonary was obvious, em-[CM(51]bolismic pulmonary tissues was not obvious, and the peak value was delayed and smooth,it indicated a statistical significant difference[CM)] (t=11.52, P0.01). The sensitivity and specificity of MR pulmonary perfusion were 95% and 85% respectively. The sensitivity and specificity of SPECT pulmonary perfusion were 100% and 65% respectively. The difference between them had no statistical significance (χ~2=2.06, P0.05). Fibrin exudation, pulmonary interstitial incrassation, thrombosis of pulmonary artery, hemorrhage and gore were found.Conclusion:MR enhanced pulmonary perfusion can diagnose pulmonary embolism. MR and SPECT pulmonary perfusion imaging had been coherent on diagnostic pulmonary embolism.