Comparison of pulmonary angiogrphy and pulmonary perfusion scan in animal model of pulmonary embolism

Objective:The study is to evaluate the use of perfusion scan in the diagnosis and therapy in animal model of pulmonary embolism.Method:8 male computer-randomised Chinese experimental pigs,with average weight 16.1±1.4 kg. 2～5 ml blood was to made emboli,and was sent to pulmonary artery by catheter to create pulmonary embolism animal model.Both chosen pulmonary angiography and nuclear perfusion scan were performed before and after creating animal model as well as thrombolytic therapy,and then two methods were compared.Result:CPA were all normal,and one didn't show well-distribution in left lung,and specificity of pulmonary perfusion scan was 87.5% (1/8).CPA showed that 5 pigs were formed into PE in 7 living pigs,and the other 2 were not clear.Compared with CPA,the sensitivity and accuracy of pulmonary perfusion scan were 100% and 90% respectively,consent with pathological autopsy.One was normal in pulmonary angiography and perfusion scan was sub-segmental embolism,and after thrombolytic therapy,pulmonary perfusion returned to normal.If the standard was that thrombolytic therapy and pulmonary angiogram was effective,the accuracy was raised to 100%,perfusion scan completely accorded with pulmonary angiogram.One CPA showed completely open,and perfusion scan partly amlieration,autopsy showed necrosis.Conclusion:The sensitivity and specificity of perfusion scan was high in diagnosing pulmonary embolism,and completely consent with pathological autopsy.Perfusion scan could be the screen before pulmonary angiogram,and the important tool to observe therapy effect.