Expression of chemokine receptor 4 and interleukin-6 in colorectal tumor and their significance in angiogenesis

Objective To investigate the expression of chemokine receptor 4(CXCR4 ) and interleukin -6(IL-6) proteins in colorectal carcinoma and determine their clinical significance through finding their association with microvessel density(MVD) and their correlations with each other. Methods Immunohistochemistry staining was used to detect the expression of CXCR4,IL-6 proteins and CD34 in 94 cases of colorectal cancer tissues.Results The respective expression levels of CXCR4 and IL-6 in colorectal cancer tissues were 72.34%and 28.72%.Expression of CXCR4 in colorectal carcinoma was correlated with invasive depth and lynph node metastasis(P0.05). Expression of IL-6 in colorectal carcinoma was not correlated to invasive depth,lynph node metastasis or tumor locus of the colorectal carcinoma.The expression of IL-6 in colorectal carcinoma was correlated with MVD.The expression of CXCR4 had no correlation with the expression of IL-6 in colorectal carcinoma.The expression of CXCR4 was positively correlated with tumor invasive depth,lymph node metastasis and MVD in patients suffering from colorectal cancer. Conclusion The increase of the expression of CXCR4 and IL-6 in colorectal cancer tissue may relate with tumor angiogenesis and they may play a key role in colorectal cancer formation and metastasis.