Expression of CXCR4 and MMP-2 in Colorectal Cancer and its Relationship with Tumor Metastasis

Objective To investigate the expressions of chemokine receptor CXCR4 and matrix metalloproteinase MMP-2 in the colorectal cancer and to study their relationship with tumor metastasis.Methods Immunohistochemical method was used to detect the expressions of CXCR4 and MMP-2 in the colorectal cancer and tumor-adjacent normal colorectal tissues.The correlation of the expressions of chemokine receptor CXCR4 and MMP-2 with the lymph node metastasis,liver metastasis and clinical stage was evaluated.Results The positive expression rates of CXCR4 in the colorectal cancer and tumor-adjacent normal colorectal tissues were 64.3% and 20.0% respectively.There was significant difference between the two groups.The positive expression rates of MMP-2 in the colorectal cancer and tumor-adjacent normal colorectal tissues were 78.5% and 30.0% respectively,and the difference was statistically significant.The expressions of CXCR4 and MMP-2 were related to the lymph node metastasis and clinical stage.Conclusion CXCR4 and MMP-2 were highly expressed in the colorectal cancer.CXCR4 and MMP-2 may promote the metastasis of colorectal cancer.