Impact of folic acid and Calomide-Me on urinary protein in patients with H type hypertensive nephropathy

Objective To investigate the impact of folic acid and Calomide-Me on urinary protein in patients with H type hypertensive nephropathy.Methods 94 patients with hypertensive nephropathy in our hospital were selected and divided into folic acid group(n=30),Calomide-Me group(n=31)and folic acid puls Calomide-Me group(n=3),according to the different kinds of drugs given to them.All of the patients were treated for 3 months on the base of routine decompression treatment,and more,HCY,BUN,SCr and 24hU-Pro of these patients were assay and compared before and after treatment.Results(1)After 3 months of treatment,HCY of the patients in the three groups were all reduced significantly(P 0.01),especially in the folic acid puls Calomide-Me group(P 0.05).(2)After treatment,there were no significant improvement on BUN,SCr of the patients in the three groups(P 0.05),however,24hU-Pro of the patients in the three groups were all reduced significantly(P 0.05),especially in the folic acid puls Calomide-Me group(P 0.01).Conclusion Using folic acid and Calomide-Me in patients with H type hypertensive nephropathy may reduce Hcy level of patients,meanwhile,may reduce urinary protein excretion in different degree and protect kidney.