Study on the Protection of JieJiu HuGan Prescription against Alcoholic Liver Injury of Rats in Different Constitutions

Objective: To observe the protective effects of JieJiu HuGan prescription on alcoholic liver injury of rats with different constitutions. Methods: All the rats were randomized into 11 groups: normal group, Yang deficiency model group, medication groups of preventing Yang deficiency(low dose group of warm-nature prescription, high dose group of warm-nature prescription, low dose group of cold-nature prescription and high dose group of cold-nature prescription), Yin deficiency model group, medication groups of preventing Yin deficiency(low dose group of warm-nature prescription, high dose group of warm-nature prescription, low dose group of cold-nature prescription and high dose group of cold-nature prescription), except normal groups, the models of Yang deficiency were established by muscular injection of hydrocortisone(30 mg/kg) and the ones of Yin deficiency by intragastric administration of thyroxine aqueous solution(25 mg/kg). According to the constitutions, the rat models were given with preventive medicine in different dosages(4.15, 0.83 g/kg, intragastric administration), after one hour, the rats were perfused with Erguotou(112 degrees proof, 0.009 mL/g), the levels of AST and ALT in the serum of the rats were detected after perfused for five consecutive weeks. Results: Compared with the normal group, AST, ALT and AST/ALT of the model group and the preventive medication groups were increased, which suggested liver injury in different degrees(P 0.05); AST and ALT were improved significantly in the high dosage group which were medicated against the constitution(P0.05); AST and ALT were decreased remarkably in the high dosage group which were medicated based on the constitution(P 0.05). Conclusion: JieJiu HuGan prescription based on the constitution could effectively prevent alcoholic liver injury of the rats.