The Observation of Clinical Effect of Therapeutic Alliance of Diacerein and Sodium Hyaluronate in Osteoarthritis Patients

Objective:To evaluate the clinical efficacy of therapeutic alliance of diacerein and sodium hyaluronate in osteoarthritis patients.Methods:There were 134 cases of knee osteoarthritis enrolled who were fulfilled with the American College of Rheumatology criterias of knee osteoarthritis,and they were divided into two groups:therapeutic alliance group and control group.Sixty-nine cases of knee osteoarthritis as therapeutic alliance group were given diacerein and sodium hyaluronate and 65 cases as control group only were given sodium hyaluronate.All patients with knee osteoarthritis were observed and followed up for six months.Results:The joint pain and pain on walking for 20 meters(visual analog scale,VAS) and WOMAC score and ESR and CRF of 134 cases of kneed osteoarthritis patients were significatively improved compared with baseline(P0.001).The joint pain and pain on walking for 20 meters and WOMAC score and ESR and CRF of therapeutic alliance group were greatly improved compared with these of control group at the last 3 months after treatment and no difference at the 1st month and the second and the 3rd month.The number of patients with knee osteoarthritis given NSAIDs was not so many as among therapeutic alliance group compared with that of control group at last 5 months(χ2=5.256,P=0.022;χ2=10.428,P=0.001) but Similar at the 1st month(χ2=0.137,P=0.711).Conclusion:Clinical efficacy of knee osteoarthritis patients with treatment on diacerein and sodium hyaluronate is better than that of sodium hyaluronate only.