The relationship between connective tissue growth factor and hepatic fibrosis

The connective tissue growth factor(CTGF) can enhance the proliferation of fibroblasts and promote the extra cellular matrix synthesis.It is an important cytokine that can promote organ fibrosis.There is a strong correlation between the CTGF and hepatic fibrosis.The CTGF expression of human hepatic fibrosis,cirrhosis and experimental hepatic fibrosis model is significantly rising.The inhibition of CTGF expression can reduce the extra cellular matrix synthesis,resulting in the inhibition of hepatic fibrosis.The further study of CTGF is important for the pathogenesis,therapeutic mechanism and the clinical treatment of hepatic fibrosis and cirrhosis.In the review,the function of CTGF and its state on the pathogenic process,diagnosis and treatment of hepatic fibrosis were summarized and discussed.