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Pharmacokinetics and Relative Bioavalability of Glipizide Tablet

Yuanda Zhou, Gaoqiong Yao

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Abstract

OBJECTIVE:To determine the pharmacokinetics and bioavalability of glipizide tablet,and to compare Chongqing glipizide tablet with that produced in Hainan.METHODS:The drug concentrations in plasma were assayed by HPLC after administration of a single oral dose of 5mg Chongqing or Hainan glipizide to each of 12 healthy male volunteers in a randomized crossover study.RESUITS:The peak plasma levels averaged (267 26±64 35)ng/ml and (260 14±43 89)ng/ml,times to reach the peak level were (2 86±0 56)h and (2 92±0 7)h,and the areas under the drug concentration curves were (1 721 53±505 17)ng/(h·ml) and (1 714 00±266 29)ng/(h·ml) for Chongqing and Hainan glipizide,respectively.CONCLUSION:The result sh_owed that the two tablets were bioequivalent.

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What this paper is about

OBJECTIVE:To determine the pharmacokinetics and bioavalability of glipizide tablet,and to compare Chongqing glipizide tablet with that produced in Hainan.METHODS:The drug concentrations in plasma were assayed by HPLC after administration of a single oral dose of 5mg Chongqing or Hainan glipizide to each of 12 healthy male volunteers in a randomized crossover study.RESUITS:The peak plasma levels averaged (267 26±64 35)ng/ml and (260 14±43 89)ng/ml,times to reach the peak level were (2 86±0 56)h and (2 92±0 7)h,and the areas under the drug concentration curves were (1 721 53±505 17)ng/(h·ml) and (1 714 00±266 29)ng/(h·ml) for Chongqing and Hainan glipizide,respectively.CONCLUSION:The result sh_owed that the two tablets were bioequivalent.

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Available abstract

OBJECTIVE:To determine the pharmacokinetics and bioavalability of glipizide tablet,and to compare Chongqing glipizide tablet with that produced in Hainan.METHODS:The drug concentrations in plasma were assayed by HPLC after administration of a single oral dose of 5mg Chongqing or Hainan glipizide to each of 12 healthy male volunteers in a randomized crossover study.RESUITS:The peak plasma levels averaged (267 26±64 35)ng/ml and (260 14±43 89)ng/ml,times to reach the peak level were (2 86±0 56)h and (2 92±0 7)h,and the areas under the drug concentration curves were (1 721 53±505 17)ng/(h·ml) and (1 714 00±266 29)ng/(h·ml) for Chongqing and Hainan glipizide,respectively.CONCLUSION:The result sh_owed that the two tablets were bioequivalent.

Key concepts: Glipizide, Bioequivalence, Pharmacokinetics, Crossover study, Pharmacology, Plasma concentration, Plasma levels, Chemistry

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